Hyaluronan and TLR4 promote surfactant-protein-C-positive alveolar progenitor cell renewal and prevent severe pulmonary fibrosis in mice

Jiurong Liang,Yanli Zhang,Ting Xie,Ningshan Liu,Huaiyong Chen,Yan Geng,Adrianne Kurkciyan,Jessica Monterrosa Mena,Barry R Stripp,Dianhua Jiang,Paul W Noble

NATURE MEDICINE（2016）

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摘要

Reduced hyaluronan–TLR4 signaling in a stem cell population of the lung contributes to a lack of renewal of these cells and promotes fibrosis in patients with idiopathic pulmonary fibrosis.

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关键词

Self-renewal,Respiratory tract diseases,Innate immunity

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