Reevaluation of anti-obesity action of mazindol and elucidation of its effect on the reward system.

Daisuke Aotani,Cheol Son,Yoshiyuki Shimizu,Hidenari Nomura,Takatoshi Hikida,Toru Kusakabe,Tomohiro Tanaka,Takashi Miyazawa,Kiminori Hosoda,Kazuwa Nakao

Neuroscience Letters（2016）

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摘要

•Mazindol reduces body weight gain and hyperphagia induced by high-fat diet.•Mazindol decreases preference for lipid emulsion.•Mazindol decreases conditioned place preference for high-fat diet.•Mazindol at the dose required for these effects does not elicit abuse potential.

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ANOVA,AUC,CPP,DIO,HFD,NCD

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