Maintaining cell identity: PRC2-mediated regulation of transcription and cancer

Itys Comet,Eva M. Riising,Benjamin Leblanc,Kristian Helin

NATURE REVIEWS CANCER（2016）

引用 357|浏览2

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摘要

In this Opinion article, the authors propose that the function of Polycomb repressive complex 2 (PRC2) in maintaining, rather than specifying, transcriptional repression can explain its seemingly contradictory roles in cancer.

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关键词

Cancer genetics,Cancer genomics,Epigenetics,Cancer epigenetics,Targeted therapies

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