Immune responses elicited by the GEN-003 candidate HSV-2 therapeutic vaccine in a randomized controlled dose-ranging phase 1/2a trial.

Jessica Baker Flechtner,Deborah Long,Shane Larson,Veronica Clemens,Amy Baccari, Lena Kien,Jason Chan,Mojca Skoberne, Matthew Brudner,Seth Hetherington

Vaccine（2016）

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摘要

•Cellular and humoral responses were boosted in GEN-003 vaccinated HSV-2 seropositive subjects.•Matrix-M2 adjuvant potentiated the immune responses to ICP4 and gD2 antigens contained in GEN-003.•No immune correlates of anti-viral activity have yet been identified.

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关键词

Herpes simplex virus,Vaccine,Immunotherapy,Immune response

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