Dicer1–miR-328–Bace1 signalling controls brown adipose tissue differentiation and function

Matteo Oliverio,Elena Schmidt,Jan Mauer, Catherina Baitzel,Nils Hansmeier, Sajjad Khani, Sandra Konieczka,Marta Pradas-Juni,Susanne Brodesser, Trieu-My Van,Deniz Bartsch,Hella S. Brönneke,Markus Heine, Hans Hilpert,Emilio Tarcitano,George A. Garinis,Peter Frommolt,Joerg Heeren,Marcelo A. Mori,Jens C. Brüning,Jan-Wilhelm Kornfeld

NATURE CELL BIOLOGY（2016）

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摘要

Kornfeld and colleagues identify miRNAs that are dysregulated in brown adipose tissue in mouse models of obesity and ageing, and show that miR-328 targets Bace1 to promote brown adipogenesis.

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关键词

Lipid signalling,miRNAs,Insulin signalling,Ageing

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