Fluorescent false neurotransmitter reveals functionally silent dopamine vesicle clusters in the striatum

Daniela B Pereira,Yvonne Schmitz,József Mészáros, Paolomi Merchant,Gang Hu,Shu Li,Adam Henke,José E Lizardi-Ortiz,Richard J Karpowicz Jr,Travis J Morgenstern,Mark S Sonders,Ellen Kanter,Pamela C Rodriguez,Eugene V Mosharov,Dalibor Sames,David Sulzer

NATURE NEUROSCIENCE（2016）

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摘要

The authors report the generation of fluorescent false neurotransmitter 200 (FFN200), a new optical probe for selectively monitoring monoamine exocytosis in cultured neurons and brain slices. Using the new tool in combination with Ca 2+ imaging, they find functionally silent dopaminergic vesicle clusters in the striatum, with impaired exocytosis at a step downstream from Ca 2+ influx.

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关键词

Synaptic vesicle exocytosis,Fluorescent dyes,Striatum

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