Sensory experience regulates cortical inhibition by inducing IGF1 in VIP neurons
NATURE(2016)
摘要
Igf1 is identified in mice as an experience-induced gene that functions cell-autonomously to increase inhibitory input onto a disinhibitory subtype of GABAergic neurons in the cortex, affecting the downstream excitation–inhibition balance within circuits that regulate visual acuity, and providing a novel example of experience modulating neural plasticity.
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关键词
Visual system,Neural circuits,Synaptic plasticity,Neurotrophic factors
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