Methyl-esterified 3-hydroxybutyrate oligomers protect bacteria from hydroxyl radicals

Janne J Koskimäki,Marena Kajula,Juho Hokkanen,Emmi-Leena Ihantola,Jong H Kim,Heidi Hautajärvi, Elina Hankala,Marko Suokas,Johanna Pohjanen,Olga Podolich,Natalia Kozyrovska,Ari Turpeinen, Mirva Pääkkönen,Sampo Mattila,Bruce C Campbell,Anna Maria Pirttilä

NATURE CHEMICAL BIOLOGY（2016）

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摘要

Methylobacterium extorquens living in shoots and roots of Pinus sylvestris expresses poly-3-hydroxybutyrate (PHB) synthase and PHB depolymerase to generate methyl-esterified dimers and trimers of 3-hydroxybutyrate that greatly increase bacterial tolerance to host-induced oxidative stress.

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关键词

Bacteria,Biosynthesis,Drug discovery,Plant sciences

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