Robust transcriptome-wide discovery of RNA-binding protein binding sites with enhanced CLIP (eCLIP)

Eric L Van Nostrand,Gabriel A Pratt,Alexander A Shishkin,Chelsea Gelboin-Burkhart,Mark Y Fang,Balaji Sundararaman,Steven M Blue,Thai B Nguyen,Christine Surka, Keri Elkins,Rebecca Stanton,Frank Rigo,Mitchell Guttman,Gene W Yeo

NATURE METHODS（2016）

引用 804|浏览14

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摘要

Enhanced CLIP yields complex libraries of RNA components of ribonucleoprotein complexes and maintains single-nucleotide resolution of binding sites. eCLIP enables large scale profiling, as demonstrated with the binding profiles of 73 RBPs in two human cancer cell lines.

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关键词

RNA sequencing,Transcriptomics,RNA metabolism,Genomic analysis

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