Acidic chitinase primes the protective immune response to gastrointestinal nematodes

Kevin M Vannella,Thirumalai R Ramalingam,Kevin M Hart,Rafael de Queiroz Prado,Joshua Sciurba,Luke Barron,Lee A Borthwick,Allen D Smith,Margaret Mentink-Kane,Sandra White,Robert W Thompson,Allen W Cheever,Kevin Bock,Ian Moore,Lori J Fitz,Joseph F Urban Jr,Thomas A Wynn

NATURE IMMUNOLOGY（2016）

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摘要

The physiological function of the mammalian chitinase AMCase is unclear. Wynn and colleagues show that it is dispensable for allergic lung inflammation but is necessary for clearance of intestinal helminths.

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关键词

Parasitic infection,Inflammation,Innate immune cells,Adaptive immunity

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