Decoding Polo-like kinase 1 signaling along the kinetochore–centromere axis

Robert F Lera,Gregory K Potts,Aussie Suzuki,James M Johnson,Edward D Salmon,Joshua J Coon,Mark E Burkard

NATURE CHEMICAL BIOLOGY（2016）

引用 35|浏览3

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摘要

chemical genetic approach to localize human Polo-like kinase 1 (Plk1) to distinct regions along the kinetochore–centromere axis combined with phosphoproteomic analysis reveals the presence of distinct Plk1 pools to mediate chromosomal segregation.

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关键词

Mass spectrometry,Kinases,Cell division,Chemical genetics

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