Chronic Stress is Associated with Reduced Circulating Hematopoietic Progenitor Cell Number: A Maternal Caregiving Model.

Kirstin Aschbacher,Jeffrey M Milush,Amanda Gilbert, Carlos Almeida,Elizabeth Sinclair,Lorrie Epling,S Marlene Grenon,Elysa J Marco,Eli Puterman,Elissa Epel

Brain, Behavior, and Immunity（2017）

引用 16|浏览12

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摘要

•Circulating hematopoietic progenitor cells (CPCs) are CD34+KDR+ and CD133+KDR+.•Low CPCs prospectively predict cardiovascular events in meta-analyses.•Chronic stress of maternal caregiving is associated with reduced CPCs.•Negative daily maternal-child interactions explain this stress-immune relationship.•As expected, low CPCs are associated with a poorer lipid profile in this sample.

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关键词

Endothelial progenitor cells (EPCs),Circulating angiogenic cells (CACs),Monocytes,Cardiovascular risk,Preclinical atherosclerosis,Cholesterol,Chronic stress,Maternal caregiving,Family interactions,Autism

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