Feedback modulation of cholesterol metabolism by the lipid-responsive non-coding RNA LeXis

The activation of lipid X receptors (LXRs) in mouse liver not only promotes cholesterol efflux but also inhibits cholesterol synthesis simultaneously; this is mediated by the lipid-responsive long non-coding RNA LeXis , which is induced by a Western diet and orchestrates crosstalk between LXRs and the cholesterol biosynthetic pathway.