Genetic identification of thiosulfate sulfurtransferase as an adipocyte-expressed antidiabetic target in mice selected for leanness
Nicholas M Morton,Jasmina Beltram,Roderick N Carter,Zoi Michailidou,Gregor Gorjanc,Clare McFadden,Martin E Barrios-Llerena,Sergio Rodriguez-Cuenca,Matthew T G Gibbins,Rhona E Aird,José Maria Moreno-Navarrete,Steven C Munger,Karen L Svenson,Annalisa Gastaldello,Lynne Ramage,Gregorio Naredo,Maximilian Zeyda,Zhao V Wang,Alexander F Howie, Aila Saari,Petra Sipilä,Thomas M Stulnig,Vilmundur Gudnason,Christopher J Kenyon,Jonathan R Seckl,Brian R Walker,Scott P Webster,Donald R Dunbar,Gary A Churchill,Antonio Vidal-Puig,José Manuel Fernandez-Real,Valur Emilsson,Simon Horvat NATURE MEDICINE（2016）
摘要
Genetic analysis in mice selected for leanness has identified thiosulfate sulfurtransferase as a target for the treatment of diabetes.
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关键词
Heritable quantitative trait,Metabolic disorders,Experimental models of disease
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