Zeb2 is essential for Schwann cell differentiation, myelination and nerve repair

Susanne Quintes,Bastian G Brinkmann, Madlen Ebert,Franziska Fröb,Theresa Kungl,Friederike A Arlt,Victor Tarabykin,Danny Huylebroeck,Dies Meijer,Ueli Suter,Michael Wegner,Michael W Sereda,Klaus-Armin Nave

NATURE NEUROSCIENCE（2016）

引用 124|浏览9

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摘要

By studying a severe neuropathy in mice, Quintes, Brinkmann et al . demonstrate that the nuclear zinc-finger protein Zeb2 (Sip1) is essential for Schwann cell differentiation and myelin synthesis. Since Zeb2 -deficient Schwann cells continuously express repressors of lineage progression, ‘inhibiting the inhibitors’ emerges as a new principle of peripheral myelination control.

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关键词

Glial development,Regeneration and repair in the nervous system,Schwann cell

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