Neuronal activity enhances tau propagation and tau pathology in vivo

Jessica W Wu,S Abid Hussaini, Isle M Bastille,Gustavo A Rodriguez,Ana Mrejeru, Kelly Rilett,David W Sanders,Casey Cook,Hongjun Fu, Rick A C M Boonen,Mathieu Herman, Eden Nahmani,Sheina Emrani,Y Helen Figueroa,Marc I Diamond,Catherine L Clelland,Selina Wray,Karen E Duff

NATURE NEUROSCIENCE（2016）

引用 521|浏览21

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摘要

The authors show that tau can be released by neurons and transferred to other neurons via the extracellular space. Moreover, they show that enhancing neuronal activity accelerates transneuronal tau propagation and exacerbates tau pathology.

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关键词

Diseases of the nervous system,Alzheimer's disease

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