FANCD2 limits replication stress and genome instability in cells lacking BRCA2

Johanna Michl,Jutta Zimmer,Francesca M Buffa,Ultan McDermott,Madalena Tarsounas

NATURE STRUCTURAL & MOLECULAR BIOLOGY（2016）

引用 73|浏览30

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摘要

Probing the synthetic lethal effect of FANCD2 deletion in BRCA2-deficient cells reveals independent roles of FANCD2 and BRCA2 in stabilizing stalled replication forks to maintain genome stability and promote cell survival.

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关键词

DNA damage and repair,Tumour-suppressor proteins

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