Recognizing millions of consistently unidentified spectra across hundreds of shotgun proteomics datasets

Johannes Griss,Yasset Perez-Riverol, Steve Lewis,David L Tabb,José A Dianes,Noemi del-Toro,Marc Rurik,Mathias Walzer,Oliver Kohlbacher,Henning Hermjakob,Rui Wang,Juan Antonio Vizcaíno

Nature Methods（2016）

引用 123|浏览22

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摘要

newly developed algorithm enabled clustering of all 256 million (66 million identified and 190 million unidentified) peptide MS/MS spectra available in the PRIDE Archive database, allowing the detection of millions of consistently unidentified spectra across different data sets, of which roughly 20% could be identified using multiple complementary analysis tools.

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关键词

Data mining,Protein databases,Proteome informatics,Proteomic analysis,Proteomics,Life Sciences,general,Biological Techniques,Biological Microscopy,Biomedical Engineering/Biotechnology,Bioinformatics

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