Identification of novel signature genes attesting arsenic-induced immune alterations in adult zebrafish (Danio rerio).

•Novel signature genes of arsenic induced immunotoxicity are identified.•Ahead of tissue specific response probable mechanism is predicted at organism level.•Arsenic induced immunotoxicity is mediated by initial immune activation.•Signature genes attesting immune activation and suppression are elucidated.•With the marker genes, possible affected pathways are proposed and compared with human.