Targeted DNA demethylation in vivo using dCas9–peptide repeat and scFv–TET1 catalytic domain fusions

Sumiyo Morita,Hirofumi Noguchi,Takuro Horii,Kazuhiko Nakabayashi,Mika Kimura,Kohji Okamura,Atsuhiko Sakai,Hideyuki Nakashima,Kenichiro Hata,Kinichi Nakashima,Izuho Hatada

NATURE BIOTECHNOLOGY（2016）

引用 355|浏览16

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摘要

DNA methyl groups are selectively removed at target loci using inactive Cas9 fused to a SunTag-based peptide repeat that recruits the enzymatic activity.

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关键词

CRISPR-Cas9 genome editing,Methylation analysis

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