Plasminogen activator inhibitor type 1 in platelets induces thrombogenicity by increasing thrombolysis resistance under shear stress in an in-vitro flow chamber model

Kazuya Hosokawa,Tomoko Ohnishi-Wada, Hisayo Sameshima-Kaneko,Tomoka Nagasato,Naoki Miura,Kiyoshi Kikuchi,Takehiko Koide,Ikuro Maruyama,Tetsumei Urano

Thrombosis Research（2016）

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摘要

•Shear rate largely modified thrombolytic efficacy of t-PA.•PAI-1 inhibitor enhanced the thrombolytic efficacy of t-PA under arterial shear rate.•PAI-1 secreted from platelets appeared to potently regulate arterial thrombolysis.

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AUC30,CFT,CT,CTI,MCF,ML,OT,PAI-1,ROTEM,T10,TEG,TF,t-PA,u-PA,WT

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