Tumor necrosis factor receptor-associated protein 1 improves hypoxia-impaired energy production in cardiomyocytes through increasing activity of cytochrome c oxidase subunit II.

Fei Xiang,Si-Yuan Ma,Dong-Xia Zhang,Qiong Zhang,Yue-Sheng Huang

The International Journal of Biochemistry & Cell Biology（2016）

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摘要

•We established a hypoxic model of cultured rat neonatal cardiomyocytes.•TRAP1 overexpression improved hypoxia-impaired ATP production.•TRAP1 depletion exacerbated hypoxia-impaired ATP production.•TRAP1 mediated the expression and activity of COXII during hypoxia.•COXII is a downstream effector of TRAP1 in mediating ATP production during hypoxia.

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关键词

Cardiomyocytes,Hypoxia,Tumor necrosis factor receptor-associated protein 1,Cytochrome c oxidase subunit II,ATP

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