A simple and efficient synthesis of novel inhibitors of alpha-glucosidase based on benzimidazole skeleton and molecular docking studies.

A novel series of benzimidazole derivatives containing ester, hydrazide, carbothioamide groups, oxadiazole, triazole and thiadiazole rings were synthesized and evaluated for α-glucosidase inhibition. Three compounds were potent inhibitors with IC50 values ranging from 10.49 to 40.45μM. This has described a new class of α-glucosidase inhibitors.