The prion protein is an agonistic ligand of the G protein-coupled receptor Adgrg6

Alexander Küffer,Asvin K. K. Lakkaraju,Amit Mogha,Sarah C. Petersen, Kristina Airich, Cédric Doucerain,Rajlakshmi Marpakwar,Pamela Bakirci,Assunta Senatore,Arnaud Monnard, Carmen Schiavi,Mario Nuvolone,Bianka Grosshans,Simone Hornemann,Frederic Bassilana,Kelly R. Monk,Adriano Aguzzi

Nature（2016）

引用 218|浏览30

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摘要

The cellular prion protein PrP C promotes peripheral myelin homeostasis by acting on a G protein-coupled receptor to increase levels of cyclic AMP in Schwann cells.

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关键词

Cellular neuroscience,Mechanisms of disease

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