Optimization of a novel series of pyranopyridine RND efflux pump inhibitors.

Current Opinion in Microbiology（2016）

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摘要

•Efflux pumps play a major role in multidrug resistance (MDR) in bacteria.•RND family efflux pumps are the major MDR pumps in the Gram-negative pathogens.•Efflux pump inhibitors (EPIs) increase antibiotic efficacy and decrease resistance.•Recent advances in optimizing novel RND-targeting pyranopyridine EPIs are reviewed.

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