An inhibitor of KDM5 demethylases reduces survival of drug-tolerant cancer cells

Nature Chemical Biology（2016）

引用 243|浏览61

暂无评分

摘要

KDM5 histone demethylases promote the survival of drug-tolerant persister (DTP) cells in certain cancers. CPI-455, a chemical probe specific for KDM5, elevates cellular H3K4 methylation levels and reduces DTP cell numbers, suggesting that KDM5 is a viable target for cancer combination treatment.

查看译文

关键词

Cancer therapy,Histone post-translational modifications,Target identification,Chemical genetics

AI 理解论文

溯源树

样例

生成溯源树，研究论文发展脉络

Chat Paper

正在生成论文摘要