Multiplex PCR assay underreports true bloodstream infections with coagulase-negative staphylococci in hematological patients with febrile neutropenia.

Reers Yvonne,Idelevich Evgeny A, Pätkau Hanna,Sauerland Maria Cristina,Tafelski Sascha,Nachtigall Irit,Berdel Wolfgang E,Peters Georg,Silling Gerda,Becker Karsten, Null Null

Diagnostic Microbiology and Infectious Disease（2016）

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摘要

SeptiFast multiplex PCR assay was evaluated for detecting true bloodstream infections (BSIs) with coagulase-negative staphylococci (CoNS) in neutropenic hematological patients. Sensitivity for samples representing true CoNS-BSIs was 23.3% with an integrated cutoff and increased to 83.3% if the cutoff was neglected. Hence, the cutoff may prohibit timely targeted antimicrobial therapy.

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关键词

Bloodstream infections,Coagulase-negative staphylococci,Multiplex PCR,Cutoff,Febrile neutropenia

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