A mechanistic evaluation of the Syrian hamster embryo cell transformation assay (pH 6.7) and molecular events leading to senescence bypass in SHE cells.

Jessica C Pickles,Kamala Pant, Lisa A Mcginty,Hemad Yasaei,Terry Roberts,Andrew D Scott,Robert F Newbold

Mutation Research/Genetic Toxicology and Environmental Mutagenesis（2016）

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摘要

•Mechanistic evaluation of SHE CTA, specific to B(a)P.•Applicability of the Syrian hamster as a relevant model of carcinogenesis.•Molecular analysis of immortal lines derived from benzo(a)pyrene-induced MT clones.•Morphological transformation (MT) does not guarantee senescence bypass.•Secondary events to MT are necessary for cellular immortalisation.

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关键词

SH,SHE,CTA

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