Global Optimization Approaches in Protein Folding and Peptide Docking

Mathematical Support for Molecular Biology(1999)

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摘要
. The recent advances in genetic engineering, high powered computing and global optimization continue to stimulate interest in the area of molecular modeling and protein structure prediction. The goal of these efforts is the ability to correctly predict native protein conformations and the binding interactions of macromolecules. These two problems currently dominate the field of computational chemistry and, through the use of detailed molecular models, they have also greatly influenced research ...
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