Segmentation of Nuclei From 3D Microscopy Images of Tissue via Graphcut Optimization.

Nuclear segmentation in 3D microscopic tissue images remains a challenge due to tight packing of the cells, low contrast and poor depth resolution. To address this problem, we developed a robust and accurate nuclear segmentation algorithm suited for tissue samples of higher organisms such as mice and humans. The study was inspired by previous works in graphcut-based segmentation in areas other tha...