Stain Specific Standardization of Whole-Slide Histopathological Images.

Babak Ehteshami Bejnordi,Geert J. S. Litjens,Nadya Timofeeva,Irene Otte-Holler,André Homeyer,Nico Karssemeijer,Jeroen A. W. M. van der Laak

IEEE Transactions on Medical Imaging（2016）

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摘要

Variations in the color and intensity of hematoxylin and eosin (H&E) stained histological slides can potentially hamper the effectiveness of quantitative image analysis. This paper presents a fully automated algorithm for standardization of whole-slide histopathological images to reduce the effect of these variations. The proposed algorithm, called whole-slide image color standardizer (WSICS), uti...

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关键词

Image color analysis,Standardization,Training,Transforms,Design automation,Robustness,Optical imaging

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