Comprehensive Drug Testing of Patient-derived Conditionally Reprogrammed Cells from Castration-resistant Prostate Cancer.

Khalid Saeed,Vesa Rahkama,Samuli Eldfors, Dmitry Bychkov,John Patrick Mpindi,Bhagwan Yadav,Lassi Paavolainen,Tero Aittokallio,Caroline Heckman,Krister Wennerberg,Donna M Peehl,Peter Horvath,Tuomas Mirtti,Antti Rannikko,Olli Kallioniemi,Päivi Östling,Taija M Af Hällström

European Urology（2017）

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摘要

Proof-of-concept study with the aim of generating patient-derived ex vivo models of prostate cancer combined with high-throughput drug testing to identify potential efficacies among 306 existing and emerging cancer drugs highlighting the effect of navitoclax in an advanced disease model.

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关键词

Castration-resistant prostate cancer,Drug sensitivity testing,Navitoclax,Patient-derived cultures,Reprogrammed cells

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