Immunogenicity of Pseudomonas aeruginosa recombinant b-type fagellin as a vaccine candidate: Protective efficacy in a murine burn wound sepsis model

Bahador Behrouz,Mehdi Mahdavi,Nour Amirmozafari,Mohammad Javad Fatemi,Gholamreza Irajian, Mahbubeh Bahroudi,Farhad B. Hashemi

Burns : journal of the International Society for Burn Injuries（2016）

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摘要

•P. aeruginosa type b flagellin induces antigen-specific immune responses.•Type b-flagellin elicits opsono-phagocytic antibodies that inhibit of PA motility.•r-b-flagellin immunization can improve survival rate of mice with wound infection.•The first report of protection against PA infection by r-b-flagellin immunization.

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关键词

Pseudomonas aeruginosa,Recombinant flagellin,Immunization,Antibody,Burn

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