Effect of Ca(2+) on Aß40 fibrillation is Characteristically Different.

International Journal of Biological Macromolecules(2016)

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摘要
•Previously, we reported enhanced acceleration of Aβ42 fibril formation by Ca2+ as compared to Aβ40 (in vitro).•We used different but scientific data treatment and parameters in this study.•We conclude, although subtle and elusive, Ca2+ at physiological concentrations and in vitro enhances Aβ40 fibrillation at monomeric, oligomeric and protofibrilar stages contrary to published reports but it is not as prominent as observed for Aβ42.
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关键词
Aβ40, Aβ42,CD,AD
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