Genetic variation: Linking TF binding to disease risk using pooled ChIP-seq.

NATURE REVIEWS GENETICS（2016）

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摘要

A pooled ChIP–seq (chromatin immunoprecipitation followed by sequencing) approach for mapping quantitative trait loci (QTLs) can identify genetic variants that affect the binding of transcription factors (TFs), according to new research published in Cell. Ultimately, this approach reveals links between binding QTLs (bQTLs), chromatin architecture and complex disease at a much lower cost compared to current… Download references

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关键词

Next-generation sequencing,Chromatin immunoprecipitation,Genetic variation,Quantitative trait loci,Transcription factors,NF-kappaB,Disease genetics

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