Validation of an LC-MS/MS salivary assay for glucocorticoid status assessment: evaluation of the diurnal fluctuation of cortisol and cortisone and of their association within and between serum and saliva.

Marco Mezzullo,Flaminia Fanelli,Alessia Fazzini,Alessandra Gambineri,Valentina Vicennati,Guido Di Dalmazi,Carlotta Pelusi,Roberta Mazza,Uberto Pagotto,Renato Pasquali

The Journal of Steroid Biochemistry and Molecular Biology（2016）

引用 35|浏览25

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摘要

•LC–MS/MS assayed salivary cortisol and cortisone parallels serum levels daily rhythm.•Cotton swab device Salivette ameliorates saliva collection and analysis.•Salivary cortisol reflects serum free cortisol and HPA axis activation.•Salivary cortisone reflects overall cortisol exposure.

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关键词

Cortisol,Cortisone,Saliva,LC–MS/MS,Circadian rhythm

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