High-efficiency antibody discovery achieved with multiplexed microscopy.
Microscopy(2016)
摘要
The analysis of secreted antibody from large and diverse populations of B cells in parallel at the clonal level can reveal desirable antibodies for diagnostic or therapeutic applications. By immobilizing B cells in microdroplets with particulate reporters, decoding and isolating them in a microscopy environment, we have recovered panels of antibodies with rare attributes to therapeutically relevan...
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关键词
antibody discovery,single B cell cloning,chicken monoclonal antibody,ion channel,GPCR,DR4 DR5
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