Low-molecular weight heparin protamine complex augmented the potential of adipose-derived stromal cells to ameliorate limb ischemia

Satoko Kishimoto,Ken-ichi Inoue,Shingo Nakamura,Hidemi Hattori,Masayuki Ishihara,Masashi Sakuma,Shigeru Toyoda,Hideki Iwaguro,Isao Taguchi,Teruo Inoue,Ken-ichiro Yoshida

Atherosclerosis（2016）

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摘要

•LH/P-MPs promote cell-to-cell interaction and the aggregation of mouse ADSCs.•When ADSC/LH/P-MP aggregates are cultured, LH/P-MPs maintain their viability.•ADSCs/LH/P-MPs promote neovascularization and prevent ischemic limb loss in mice.•Use of ADSC/LH/P-MPs offers a convenient treatment method in ischemic diseases.

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关键词

Limb ischemia,Adipose-derived stromal cells,Low-molecular-weight heparin/protamine micro/nanoparticles,Angiogenesis therapy,Neovascularization

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