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Discovery and Optimization of Potent, Selective, and in Vivo Efficacious 2-Aryl Benzimidazole BCATm Inhibitors.

Hongfeng Deng,Jingye Zhou,Flora Sundersingh,Jeffrey A. Messer,Donald O. Somers,Myriam Ajakane,Christopher C. Arico-Muendel,Arthur Beljean,Svetlana L. Belyanskaya,Ryan Bingham, Emily Blazensky,Anne-Benedicte Boullay,Eric Boursier,Jing Chai,Paul Carter,Chun-Wa Chung,Alain Daugan,Yun Ding,Kenny Herry,Clare Hobbs,Eric Humphries,Christopher Kollmann,Van Loc Nguyen,Edwige Nicodeme,Sarah E. Smith,Nerina Dodic,Nicolas Ancellin

ACS Medicinal Chemistry Letters（2016）

Cited 39|Views44
Key words
BCATm,branched chain amino acids (BCAAs),DNA Encoded Library,ELT,2-aryl benzimidazole
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