The GBA, DYRK1A and MS4A6A polymorphisms influence the age at onset of Chinese Parkinson patients

Kuan Fan,Bei-sha Tang,Ya-qin Wang,Ji-feng Kang, Kai Li,Zhen-hua Liu,Qi-ying Sun,Qian Xu,Xin-xiang Yan,Ji-feng Guo

Neuroscience Letters（2016）

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摘要

•Systematically analyze the relationships between 18 SNPs and the age at onset (AAO) of PD.•To most of these SNPs, their relationships with AAO of PD have not been studied before.•This is the first report of the association between DYRK1A or MS4A6A gene with AAO of PD.•The effect of DYRK1A and MS4A6A gene in AD indicates the possibility that AD and PD share common pathways.

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关键词

Parkinson’s disease,Alzheimer’s disease,Age at onset

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