GABRA3 promotes lymphatic metastasis in lung adenocarcinoma by mediating upregulation of matrix metalloproteinases

    Oncotarget, 2016.

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    Keywords:
    GABRA3JNK/AP-1MMPlymphatic metastasisnon-small cell lung cancer

    Abstract:

    Tumor metastasis is the main reason for the poor prognosis of lung cancer patients. The GABAA receptor subunit GABRA3 is reportedly upregulated in lung cancer. Herein, we show that high GABRA3 protein expression in lung adenocarcinoma correlated positively with disease stage, lymphatic metastasis status and poor patient survival. In addit...More

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