Newly established myeloma-derived stromal cell line MSP-1 supports Multiple Myeloma proliferation, migration, and adhesion and induces drug resistance more than normal-derived stroma.

Pilar de la Puente, Nancy Quan,Ryan Soo Hoo,Barbara Muz,Rebecca C Gilson,Micah Luderer,Justin King,Samuel Achilefu,Noha Nabil Salama,Ravi Vij,Abdel Kareem Azab

HAEMATOLOGICA（2016）

引用 12|浏览29

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摘要

The effects of a normal bone marrow (BM) microenvironment compared to a malignant microenvironment on multiple myeloma (MM) are significantly different, where BM stromal cells (BMSCs) play a key role. We established, characterized and compared a myeloma-derived stromal cell line (Myeloma Stromal

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关键词

stroma,malignant microenvironment,multiple myeloma,new cell line

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