LXR activation protects hippocampal microvasculature in very old triple transgenic mouse model of Alzheimer's disease.

Adrián G Sandoval-Hernández,Alejandro Restrepo,Gloria P Cardona-Gómez,Gonzalo Arboleda

Neuroscience Letters（2016）

引用 19|浏览5

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摘要

•GW3965 reduced GFAP expression in the hippocampi of 3xTg-AD mice.•GW3965 partially restores LRP1 levels in neurons of 3xTg-AD.•GW3965 restores microvasculature length of 3xTg-AD mice.•GW3965 decreased Aβ deposition in blood vessels of 3xTg-AD mice.

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关键词

AD,BBB,Aβ,LRP1,LXR,GFAP,Iba1

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