Rolipram improves cognition, reduces anxiety- and despair-like behaviors and impacts hippocampal neuroplasticity after transient global cerebral ischemia.

Lígia Mendes Soares,Jochen De Vry,Harry W M Steinbusch,Humberto Milani,Jos Prickaerts,Rúbia M Weffort de Oliveira

Neuroscience（2016）

引用 58|浏览14

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摘要

•Rolipram improves cognition, reduces anxiety- and despair-like behaviors after BCCAO.•Rolipram decreases hippocampal neurodegeneration induced by BCCAO.•Rolipram increases DCX- and MAP-2 expression in the hippocampus of BCCAO mice.

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关键词

BCCAO,BLA,cAMP,CREB,DAB,DCX,DCX-IR,EZM,FST,GCL,MAP-2,MAP-2,OF,OLT,PDE-4,PKA,SGZ

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