Different effects of the nonsteroidal anti-inflammatory drugs meclofenamate sodium and naproxen sodium on proteasome activity in cardiac cells.

Rajeshwary Ghosh,Soyun M Hwang,Ziyou Cui,Jennifer E Gilda,Aldrin V Gomes

Journal of Molecular and Cellular Cardiology（2016）

引用 22|浏览8

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摘要

The use of nonsteroidal anti-inflammatory drugs (NSAIDs) like meclofenamate sodium (MS), used to reduce pain, has been associated with an increased risk of cardiovascular disease (CVD). Naproxen (NAP), another NSAID, is not associated with increased risk of CVD. The molecular mechanism(s) by which NSAIDs induce CVD is unknown.

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关键词

Cardiac cells,Cell death,Nonsteroidal anti-inflammatory drugs,Mitochondria,Proteasome,Reactive oxygen species

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