7,8-dihydroxyflavone protects 6-OHDA and MPTP induced dopaminergic neurons degeneration through activation of TrkB in rodents.

Dandan Luo, Ying Shi, Jun Wang,Qing Lin,Yi Sun,Keqiang Ye,Qiao Yan,Hai Zhang

Neuroscience Letters（2016）

引用 31|浏览6

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摘要

•7,8-DHF alleviated akinesia of 6-OHDA rat model of parkinsonism by protecting dopaminergic neurons.•7,8-DHF elevated TrkB phosphorylation in the SN in 6-OHDA rat model.•7,8-DHF protected acute MPTP neurotoxicity in mice.

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关键词

7,8-dihydroxyflavone,Neuroprotection,Brain derived neurotrophic factor,6-hydroxydopamine,MPTP,Parkinson’s disease

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