DNA polymerase-α regulates the activation of type I interferons through cytosolic RNA:DNA synthesis

NATURE IMMUNOLOGY（2016）

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摘要

The causative mechanism for the immunodeficiency and autoinflammatory disease XLPDR is unknown. Burstein and colleagues show that XLPDR is caused by disruption of POLA1 , which encodes a DNA polymerase subunit; this, in turn, leads to dysregulated production of type I interferons.

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关键词

Immunoprecipitation,Autoimmune diseases,DNA,Pattern recognition receptors,Primary immunodeficiency disorders

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