Two-way antigenic cross-reactivity between porcine epidemic diarrhea virus and porcine deltacoronavirus.

•No cross-neutralization was detected between PEDV and PdCV.•A two-way cross-reactivity was detected between PEDV and PdCV.•Conserved epitope(s) in viral N proteins may contribute to antigenic cross-reactivity.•Prevention of PEDV and PdCV will require the development of separate virus-specific vaccine products.