Procedural learning as a measure of functional impairment in a mouse model of ischemic stroke.

•In this study, we examined functional deficits in a murine stroke model (MCAO).•MCAO caused significant impairments in the rotarod and amphetamine tests.•In an operant task, MCAO affected the way mice learned a motor sequence.•This finding is congruent with cognitive impairments experienced by stroke victims.