cGAS-STING do it again: pivotal role in RNase H2 genetic disease.

EMBO JOURNAL(2016)

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摘要
RNase H2 is a susceptibility gene for the Aicardi-Goutieres syndrome (AGS), a genetic auto-inflammatory disease. Mackenzie and colleagues now report a tractable mouse model for the disease, implicating the cGAS-STING pathway.
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